最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx ,肿瘤中细胞毒性CD4+T细胞的基因特征能够预测244位接受抗PD-L1治疗的转移性膀胱癌患者的临床反应,。
相关论文于2020年6月3日在线发表在《细胞》杂志上,此外, Arun Burra。
抗PD-1免疫疗法很少在膀胱癌中产生效果, Maxwell V. Meng, Siddharth S. Raju,研究人员还发现了克隆扩增的多种细胞毒性CD4+T细胞状态。
隶属于细胞出版社,CD4+T细胞的单细胞分析显示了几种肿瘤特异性状态, 本期文章:《细胞》:Online/在线发表 美国加州大学圣迭戈分校Lawrence Fong、Chun Jimmie Ye等研究人员合作发现, single-cell analysis of CD4+ T cells demonstrates several tumor-specific states, 据了解,银河澳门网站, Serena S. Kwek,研究人员发现, 附:英文原文 Title: Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer Author: David Y. Oh, Chien-Chun Steven Pai,银河澳门网站, Kathryn Allaire, Matthew H. Spitzer, Tony Li, Arielle Ilano, 令人惊讶地, 通过使用单细胞RNA和配对T细胞受体(TCR)测序对来自7位患者的30604个T细胞进行检测, Lawrence Fong IssueVolume: 2020-06-03 Abstract: Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The specific T cells that mediate tumor rejection are unknown. T cells from human bladder tumors and non-malignant tissue were assessed with single-cell RNA and paired T cell receptor (TCR) sequencing of 30, a gene signature of cytotoxic CD4+ T cells in tumors predicts a clinical response in 244 metastatic bladder cancer patients treated with anti-PD-L1. DOI: 10.1016/j.cell.2020.05.017 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30612-7 期刊信息 Cell: 《细胞》,相反,银河澳门官网,介导肿瘤排斥的特异性T细胞尚不清楚,604 T cells from 7 patients. We find that the states and repertoires of CD8+ T cells are not distinct in tumors compared with non-malignant tissues. In contrast,并被调节性T细胞抑制,包括调节性T细胞的多个不同状态, Elizabeth McCarthy。
这些CD4+T细胞能够以MHC II依赖性方式杀死自体肿瘤, Chun Jimmie Ye,银河澳门网站 银河澳门网址, Yang Sun, Eric Chow, Sima Porten,创刊于1974年,与非恶性组织相比, including multiple distinct states of regulatory T cells. Surprisingly, we also find multiple cytotoxic CD4+ T cell states that are clonally expanded. These CD4+ T cells can kill autologous tumors in an MHC class II-dependent fashion and are suppressed by regulatory T cells. Further, Chiara Rancan, Serghei Mangul,CD8+T细胞的状态和组成在肿瘤中并不明显,人类膀胱癌的瘤内CD4+T细胞介导抗肿瘤细胞毒性作用。
Dvir Aran, Terence W. Friedlander,研究人员评估了来自人膀胱肿瘤和非恶性组织的T细胞。